このページには、自然免疫応用技研（株）創業者およびその共同研究者によるLPSおよびマクロファージに関係する学術論文（査読付き）を掲載しています。

■Lipopolysaccharide Derived from Pantoea agglomerans Directly Promotes the Migration of Human Keratinocytes
Hiroyuki Inagawa, Takashi Nishizawa, Chie Kohchi, Gen-Ichiro Soma.
In Vivo. 38(5): 2172-2178 | https://doi.org/10.21873/invivo.13680 (2024)

■Restoration of Spatial Learning Through Oral Administration of Lipopolysaccharides in Diabetes-related Cognitive Dysfunction
Hiroyuki Inagawa, Masataka Oda, Vindy Tjendana Tjhin, Chie Kohchi, Gen-Ichiro Soma.
In Vivo. 38(5): 2190-2196 | https://doi.org/10.21873/invivo.13682 (2024)

■Baseline data collections of lipopolysaccharide content in 414 herbal extracts and its role in innate immune activation.
Vindy Tjendana Tjhin, Masataka Oda, Masashi Yamashita, Tomoko Iwaki, Yasuko Fujita, Koji Wakame, Hiroyuki Inagawa, Gen-Ichiro Soma.
Sci. Rep. 14: 15394 | https://doi.org/10.1038/s41598-024-66081-2 (2024)

■Pantoea agglomerans Lipopolysaccharide Controls Nasal Discomfort—A Placebo-Controlled, Randomized, Double-Blind, Parallel-Group Comparison Trial
Chie Kohchi, Miyuki Uehiro, Taisuke Fukaya, Norikazu Watanabe, Hiroyuki Inagawa, Gen-Ichiro Soma.
Int. J. Transl. Med. 4: 126–139 | https://doi.org/10.3390/ijtm4010006 (2024)

■Effects of oral administration of lipopolysaccharide derived from Pantoea agglomerans on innate immunity of mammary glands in dairy goats.
Naoki Suzuki, Fika Yuliza Purba, Hiroyuki Inagawa, Yoshinori Hattori, Naoki Isobe.
Vet. Immunol. Immunopathol.265: 110664 | https://doi.org/10.1016/j.vetimm.2023.110664 (2023)

■Utility of In Vitro Cellular Models of Low-Dose Lipopolysaccharide in Elucidating the Mechanisms of Anti-Inflammatory and Wound-Healing-Promoting Effects of Lipopolysaccharide Administration In Vivo.
Teruko Honda, Hiroyuki Inagawa.
Int. J. Mol. Sci. 24: 14387 | https://doi.org/10.3390/ijms241814387 (2023)

■Foods Containing Pantoea agglomerans LPS Reduce Eye-Nose Allergies—A Double-Blind, Placebo-Controlled, Randomized, Parallel-Group Comparative Pilot Study.
Chie Kohchi, Miyuki Uehiro, Masashi Yamashita, Hiroyuki Inagawa, Gen-Ichiro Soma.
Int. J. Transl. Med. 3: 299–309 | https://doi.org/10.3390/ijtm3030021 (2023)

■Oral route lipopolysaccharide as a potential dementia preventive agent inducing neuroprotective microglia.
Haruka Mizobuchi.
Frontiers in Immunology, | https://doi.org/10.3389/fimmu.2023.1110583 (2023)

■Oral Administration of Lipopolysaccharide Enhances Insulin Signaling-Related Factors in the KK/Ay Mouse Model of Type 2 Diabetes Mellitus.
Kazushi Yamamoto, Masashi Yamashita, Masataka Oda, Vindy Tjendana Tjhin, Hiroyuki Inagawa, Gen-Ichiro Soma.
International Journal of Molecular Sciences 24(5):4619 | https://doi.org/10.3390/ijms24054619 (2023)

■Effect of topical application of lipopolysaccharide on contact hypersensitivity
Manami Tanaka, Chie Kohchi, Hiroyuki Inagawa, Takeshi Ikemoto, Mariko Hara-Chikuma.
Biochemical and Biophysical Research Communications 586: 100-106 | https://doi.org/10.1016/j.bbrc.2021.11.045 (2022)

■敏感肌に対するリポポリサッカライドの有効性～バリア機能の改善～
河内千恵，竹馬真理子，濱田和人，池本毅，筒井翔子，稲川裕之，杣源一郎.
J. Soc. Cosmet. Chem. Jpn. 55（4）: 338-345 (2021)

■Prevention of Diabetes-Associated Cognitive Dysfunction Through Oral Administration of Lipopolysaccharide Derived From Pantoea agglomerans
Haruka Mizobuchi, Kazushi Yamamoto, Masashi Yamashita, Yoko Nakata, Hiroyuki Inagawa, Chie Kohchi and Gen-Ichiro Soma.
Frontiers in Immunology | https://doi.org/10.3389/fimmu.2021.650176 (2021)

■Regulation of Plasminogen Activator Inhibitor-1 in Adipocytes by Macrophages Activated by Low-dose Lipopolysaccharide.
Teruko Honda, Hiroyuki Inagawa.
Anticancer Research 41: 4071-4076 (2021)

■Oral Administration of Lipopolysaccharide Prevents Cognitive Impairment in Streptozotocin-induced Diabetic Mice in a Blood Glucose-independent Manner.
Haruka Mizobuchi, Kazushi Yamamoto, Masashi Yamashita, Hiroyuki Inagawa, Chie Kohchi, Gen-Ichiro Soma.
Anticancer Research 41: 4053-4059 (2021)

■Prevention of streptozotocin‑induced Neuro‑2a cell death by C8‑B4 microglia transformed with repetitive low‑dose lipopolysaccharide.
Haruka Mizobuchi, Kazushi Yamamoto, Masashi Yamashita, Hiroyuki Inagawa, Chie Kohchi, Gen‑Ichiro Soma.
Molecular Medicine Reports 24: 687 | https://doi.org/10.3892/mmr.2021.12328 (2021)

■Low-dose lipopolysaccharide as an immune regulator for homeostasis maintenance in the central nervous system through transformation to neuroprotective microglia.
Haruka Mizobuchi, Gen-Ichiro Soma.
Neural Regeneration Research. 16 (10)｜https://doi.org/10.4103/1673-5374.308067 (2021) 総説

■Enhanced Effect of Hyaluronan and Elastin Synthesis in Fibroblasts Through Lipopolysaccharide-activated Macrophages.
Teruko Honda, Shoko Tsutsui, Chie Kohchi, Hiroyuki Inagawa.
Anticancer Res. 40: 4681-4685 (2020)

■A unique hybrid characteristic having both pro- and anti-inflammatory phenotype transformed by repetitive low dose lipopolysaccharide in C8-B4 microglia.
Haruka Mizobuchi, Kazushi Yamamoto, Shoko Tsutsui, Masafumi Yamashita, Yoko Nakata, Hiroyuki Inagawa, Chie Kohchi, Gen-Ichiro Soma.
Scientific Reports.10: 8945 | https://doi.org/10.1038/s41598-020-65998-8 (2020)

■Subchronic (90-day) toxicity assessment of Somacy-FP100, a lipopolysaccharide-containing fermented wheat flour extract from Pantoea agglomerans.
Kirt R. Phipps, Christina Sulaiman, Ryan Simon, Shivakumar Holalagoudar, Chie Kohchi, Yoko Nakata.
Journal of applied toxicology. DOI: 10.1002/jat.3987 (2020)

■Useful Cases of Patients With Developmental Disorders Improved by Oral Administration of LPS Derived from Pantoea agglomerans.
Atsutomo Morishima, Ran Zhang, Takema Nagaoka, Hiroyuki Inagawa.
Anticancer Res. 40 (8): 4755-4762 (2020)

■Attempt to Construct an In Vitro Model of Enhancement of Macrophage Phagocytosis Via Continuous Administration of LPS.
Kazushi Yamamoto, Haruka Mizobuchi, Masashi Yamashita, Hiroyuki Inagawa, Chie Kohchi, Gen-Ichiro Soma.
Anticancer Res. 40 (8): 4711-4717 (2020)

■Enhanced Effect of Hyaluronan and Elastin Synthesis in Fibroblasts Through Lipopolysaccharide-activated Macrophages.
Teruko Honda, Shoko Tsutsui, Chie Kohchi, Hiroyuki Inagawa.
Anticancer Res. 40 (8): 4681-4685 (2020)

■A Novel Anti-inflammatory Phenotype Transformed by Repetitive Low-dose Lipopolysaccharide in Primary Peritoneal Tissue-resident Macrophages.
Haruka Mizobuchi, Kazushi Yamamoto, Masafumi Yamashita, Hiroyuki Inagawa, Chie Kohchi, Gen-Ichiro Soma.
Anticancer Res. 40 (8): 4457-4464 (2020)

■A unique hybrid characteristic having both pro- and anti-inflammatory phenotype transformed by repetitive low-dose lipopolysaccharide in C8-B4 microglia.
Mizobuchi H, Yamamoto K, Tsutsui S, Yamashita M, Nakata Y, Inagawa H, Kohchi C, Soma GI. Scientific Reports. 10: 8945 (2020)

■TLR4 Reactivity of Gluconacetobacter（Gluconacetobacter hansenii GK‒1）and Their Synergistic Action with Lactobacillus in Producing Antiallergic Effects.
木村守, 大江眞理子, 奥山洋平, 吉岡智史, 稲川裕之.
Jpn Pharmacol Ther（薬理と治療）47 (12): 2001-6 (2019)

■Pollen Allergy Suppression Effect by the Oral Administration of Acetic Acid Bacteria (Gluconacetobacter hansenii).
Inagawa H, Nishizawa T, Kochi C, Amano S, Soma GI.
Anticancer Res. 39 (8): 4511-4516 (2019)

■Preventive Effect of Oral Administration of Pantoea agglomerans-derived LPS in a Hypertensive Rat Model Upon Salt Loading.
Zhang R, Inagawa H, Uchibori S, Masaki T, Kobara H, Soma GI.
Anticancer Res. 39 (8): 4503-4509 (2019)

■The Effect of Lipopolysaccharide-containing Moisturizing Cream on Skin Care in Patients With Mild Atopic Dermatitis.
Kozo Nakai, Yasuo Kubota, Gen-Ichiro Soma, Chie Kohchi.
In Vivo. 33 (1):109-114 (2019)

■Usefulness of Monocytes/macrophages Activated With Low-dose Lipopolysaccharide in Tumor Tissue and Adipose Tissue of Obesity.
Honda T, Inagawa H.
Anticancer Res. 39 (8): 4475-4478 (2019) 総説

■Lipopolysaccharide-treated Human Monocytes Regulate Gene Expressions After Interactions with Human Adipocytes.
Teruko Honda, Hiroyuki Inagawa.
Biomed J Sci & Tech Res 7 (4): 5975-5979 (2018)

■Oral administration of Pantoea agglomerans derived lipopolysaccharide prevents metabolic dysfunction and Alzheimer's disease-related memory loss in senescence accelerated prone 8 (SAMP8) mice fed a high-fat diet.
Yutaro Kobayashi, Hiroyuki Inagawa, Chie Kohchi, Kimiko Kazumura, Hiroshi Tsuchiya5, Toshiyuki Miwa, Katsuichiro Okazaki, Gen-Ichiro Soma.
PLoS One 1. 13 (6): e0198493 (2018)

■Oral administration of Pantoea agglomerans derived lipopolysaccharide prevents development of atherosclerosis in high-fat diet-fed apoE-deficient mice via ameliorating hyperlipidemia, pro-inflammatory mediators and oxidative responses.
Yutaro Kobayashi, Hiroyuki Inagawa, Chie Kohchi, Kimiko Kazumura, Hiroshi Tsuchiya5, Toshiyuki Miwa, Katsuichiro Okazaki, Gen-Ichiro Soma.
PLoS One 1. 13 (3): e0195008 (2018)

■Improvement in Protracted Wound Healing by Topical Cream Containing Lipopolysaccharide Derived from Pantoea agglomerans.
Morishima A, Inagawa H.
Anticancer Res. 38 (7):4375-4379 (2018)

■Lipopolysaccharides Derived from Pantoea agglomerans Can Promote the Phagocytic Activity of Amyloid β in Mouse Microglial Cells
Yutaro Kobayashi, Hiroyuki Inagawa, Chie Kohchi, Katsuichiro Okazaki.
Anticancer Res. 37 (7):3 917-3920 (2017)

■Characterization of the O-antigen polysaccharide derived from Pantoea agglomerans IG1 lipopolysaccharide.
Masahito Hashimoto, Rune Satou, Mami Ozono, Hiroyuki Inagawa, Gen-Ichiro Soma.
Carbohydr Res. 8: 449: 32-36 (2017)

■Effects of 3 months continuous intake of supplement containing Pantoea agglomerans LPS to maintain normal bloodstream in adults: Parallel double-blind randomized controlled study.
Yoko Nakata, Chie Kohchi1, Kazue Ogawa, Takeru Nakamoto, Hiroshi Yoshimura, Gen-Ichiro Soma.
Food Sci Nutr. 6 (1): 197-206 (2017)

■自然免疫を制御するパントエア菌LPS の飲水投与による犬の肥満抑制効果.
小久保貴史, 石原裕子, 古賀浩一, 神明良典, 高木俊輔, 萩田倫子, 小椋 功, 小早川克史, 稲川裕之. InfoVets, 5 (181): (2016)

■Clinical Effects of Orally Administered Lipopolysaccharide Derived from Pantoea agglomerans on Malignant Tumors.
Atsutomo Morishima, Hiroyuki Inagawa.
Anticancer Res. 36 (7): 3747-51 (2016)

■Effect of Lipopolysaccharide Derived from Pantoea agglomerans on the Phagocytic Activity of Amyloid β by Primary Murine Microglial Cells.
Yutaro Kobayashi, Hiroyuki Inagawa5, Chie Kohchi, Katsuichiro Okazaki, Ran Zhang, Gen-Ichiro Soma.
Anticancer Res. 36 (7): 3693-8 (2016)

■Gene Expression in Lipopolysaccharide-treated Human Monocytes Following Interaction with Hepatic Cancer Cells.
Honda T, Inagawa H.
Anticancer Res. 36 (7): 3699-704 (2016)

■Immunopotentiator from Pantoea agglomerans 1 (IP-PA1) Promotes Murine Hair Growth and Human Dermal Papilla Cell Gene Expression.
Koji Wakame, Hiroshi Okawa, Ken-Ich Komatsu, Akifumi Nakata, Keisuke Sato, Hiroyuki Ingawa, Chie Kohchi, Takashi Nishizawa, Gen-Ichiro Soma.
Anticancer Res. 36 (7): 3687-92 (2016)

■Primed Activation of Macrophages by Oral Administration of Lipopolysaccharide Derived from Pantoea agglomerans.
Hiroyuki Inagawa, Yutaro Kobayashi, Chie Kohchi, Ran Zhang, Yasuhiro Shibasaki, Gen-Ichiro Soma.
In Vivo. 30 (3): 205-11 (2016)

■Immunopotentiator from Pantoea agglomerans Prevents Atopic Dermatitis Induced by Dermatophagoides farinae Extract in NC/Nga Mouse.
Koji Wakame, Ken-Ich Komatsu, Hiroyuki Inagawa, Takashi Nishizawa.
Anticancer Res. 35(8):4501-8 (2015)

■Oral Administration of Lipopolysaccharide of Acetic Acid Bacteria Protects Pollen Allergy in a Murine Model.
Satoko Amano, Hiroyuki Inagawa, Yoko Nakata, Masaki Ohmori, Chie Kohchi, Gen-Ichiro Soma.
Anticancer Res. 35(8):4509-14 (2015)

■Innate Immunity Activated by Oral Administration of LPSp Is Phylogenetically Preserved and Developed in Broiler Chickens.
Tsutomu Komori, Keiko Saito, Noriyuki Sawa, Yasuhiro Shibasaki, Chie Kohchi, Gen-Ichiro Soma, Hiroyuki Inagawa.
Anticancer Res. 35(8):4461-6 (2015)

■Molecular Response of Human Monocytes Following Interaction with Colon Cancer Cells by Pre-treatment with Low-dose Lipopolysaccharide.
Teruko Honda, Hiroyuki Inagawa.
Anticancer Res. 35(8):4473-7 (2015)

■Methods to Prevent or Treat Refractory Diseases by Focusing on Intestinal Microbes Using LPS and Macrophages.
Gen-Ichiro Soma, Hiroyuki Inagawa.
Anticancer Res. 35 (8): 4393-6 (2015) 総説

■Expression of Chemotaxis- and Angiogenesis-related Factors in Human Monocytes Following Interaction with Colon Cancer Cells Is Suppressed by Low-dose Lipopolysaccharide.
Teruko Honda, Hiroyuki Inagawa, Isamu Yamamoto.
Anticancer Res. 34 (8): 4609-13 (2014).

■Pantoea agglomerans lipopolysaccharide maintains bone density in premenopausal women: a randomized, double-blind, placebo-controlled trial.
Kazue Nakata, Yoko Nakata, Hiroyuki Inagawa, Takeru Nakamoto, Hiroshi Yoshimura, Gen-Ichiro Soma.
Food Sci Nutr. 2 (6): 638-46 (2014)

■Usefulness of Oral Administration of Lipopolysaccharide for Disease Prevention Through the Induction of Priming in Macrophages.
Hiroyuki Inagawa, Chie Kohchi, Gen-Ichiro Soma.
Anticancer Res. 34 (8): 4497-501 (2014) 総説

■Induction of Nitric Oxide Production in RAW264.7 Cells under Serum-free Conditions by O-antigen Polysaccharide of Lipopolysaccharide.
Takeshi Kadowaki, Shiho Ohno, Yoshie Taniguchi, Hiroyuki Inagawa, Chie Kohchi, Gen-Ichiro Soma.
Anticancer Res. 33 (7): 2875-9 (2013)

■Orally administered LPS enhances head kidney macrophage activation with down-regulation of IL-6 in common carp (Cyprinus carpio).
Takeshi Kadowaki, Yasumasa Yasui, Osamu Nishimiya, Yukinori Takahashi, Chie Kohchi, Gen-Ichiro Soma, Hiroyuki Inagawa.
Fish Shellfish Immunol. 34 (6): 1569-75 (2013)

■Effects of Interactions Between Intestinal Microbiota and Intestinal Macrophages on Health.
Kazue Nakata, Mai Yamamoto, Hiroyuki Inagawa, Gen-Ichiro Soma.
Anticancer Res. 33 (7): 2849-53 (2013)

■小動物に対するアトピー・アレルギー性疾患への新しいアプローチ方法
稲川裕之, 河内千恵, 杣源一郎, 木田晃子, 大川博, 澤則之.
Companion Animal Practice, 5 (2012)

■Genome Sequence of Pantoea agglomerans Strain IG1.
Tomohiko Matsuzawa, Kazuki Mori, Takeshi Kadowaki, Misato Shimada, Kosuke Tashiro, Satoru Kuhara, Hiroyuki Inagawa, Gen-ichiro Soma, and Kaoru Takegawa.
J Bacteriol. 194 (5): 1258-9 (2012)

■サラシア茶とIP-PA1混合物による糖尿病予防効果
中田和江, 谷口芳枝, 吉岡典子, 吉田彩, 稲川裕之, 中本尊, 吉村寛志, 三宅信一郎, 河内千恵, 黒木正秀, 杣源一郎.
New Food Industry. 54 (2): 25-35 (2012)

■The Involvement of O-Antigen Polysaccharide in Lipopolysaccharide in Macrophage Activation.
Misato Shimada, Takeshi Kadowaki, Yoshie Taniguchi, Hiroyuki Inagawa, Katsuichiro Okazaki, Gen-Ichiro Soma.
Anticancer Res. 32 (6): 2337-41 (2012) 総説

■Reconsideration of Macrophage and Dendritic Cell Classification.
Takeshi Kadowaki, Misato Shimada, Hiroyuki Inagawa, Chie Kohchi, Mitsuomi Hirashima, Gen-Ichiro Soma.
Anticancer Res. 32 (6): 2257-61 (2012) 総説

■A mixture of Salacia oblonga extract and IP-PA1 reduces fasting plasma glucose (FPG) and low-density lipoprotein (LDL) cholesterol levels.
Kazue Nakata, Yoshie Taniguchi, Noriko Yoshioka, Aya Yoshida, Hiroyuki Inagawa, Takeru Nakamoto, Hiroshi Yoshimura, Shin-ichiro Miyake, Chie Kohchi, Masahide Kuroki and Gen-Ichiro Soma.
Nutr Res Pract. 5 (5): 435-42 (2011)

■Oral Adminitsration of Immunopotentiator from Pantoea agglomerans 1 (IP-PA1) Improves the Survival of B16 Melanoma-Inoculated Model Mice.
Hebishima T1, Matsumoto Y, Watanabe G, Soma G, Kohchi C, Taya K, Hayashi Y, Hirota Y.
Exp Anim. 60 (2): 101-9 (2011)

■Functional Characterization of Lipopolysaccharide derived from Symbiotic Bacteria in Rice as a Macrophage-activating Substance.
Takeshi Kadowaki, Hiroyuki Inagawa, Chie Kohchi, Mitsuomi Hirashima, Gen-Ichiro Soma.
Anticancer Res. 31 (7): 2467-76 (2011)

■Anti-lipopolysaccharide Factor Evokes Indirect Killing of Virulent Bacteria in Kuruma Prawn.
Takeshi Kadowaki, Hiroyuki Inagawa, Chie Kohchi, Takashi Nishizawa, Yukinori Takahashi, Gen-Ichiro Soma.
In Vivo. 25 (5): 741-4 (2011)

■Oral administration of lipopolysaccharides for the prevention of various diseases: benefit and usefulness.
Inagawa H, Kohchi C, Soma G.
Anticancer Res. 31(7):2431-6 (2011) 総説

■Lipopolysaccharide IP-PA1 from Pantoea agglomerans Prevents Suppression of Macrophage Function in Stress-induced Diseases.
Kazue Nakata, Hiroyuki Inagawa, Gen-Ichiro Soma.
Anticancer Res. 31 (7): 2437-40 (2011) 総説

■Protective Effects of the Immunopotentiator from Pantoea agglomerans 1 on Chemotherapeutic Agent-induced Macrophage Growth Inhibition.
Takehisa Hebishima, Yasunobu Matsumoto, Gen Watanabe, Gen-Ichiro Soma, Chie Kohchi, Kazuyoshi Taya, Yoshihiro Hayashi, Yoshikazu Hirota.
Anticancer Res. 30 (6): 2033-40 (2010)

■Antitumor Effect of Inhalatory Lipopolysaccharide and Synergetic Effect in Combination with Cyclophosphamide.
Keiji Hirota, Yusuke Oishi, Hiroaki Taniguchi, Keiichi Sawachi, Hiroyuki Inagawa, Chie Kohchi, Gen-Ichiro Soma, Hiroshi Terada.
Anticancer Res. 30 (8): 3129-34 (2010)

■Lipopolysaccharide-activated Alveolar Macrophages Having Cytotoxicity toward Lung Tumor Cells through Cell-to-Cell Binding-dependent Mechanism.
Hiroaki Taniguchi, Yasuteru Shimada, Keiichi Sawachi, Keiji Hirota, Hiroyuki Inagawa, Chie Kohchi, Gen-Ichiro Soma, Kimiko Makino, Hiroshi Terada.
Anticancer Res. 30 (8): 3159-65 (2010)

■Preparation of Lipopolysaccharide Derived from Pantoea agglomerans Labeled with Fluorescence as a Tracer for Kinetics Analysis.
Takeshi Kadowaki, Hiroyuki Inagawa, Chie Kohchi1, Mitsuomi Hirashima, Gen-Ichiro Soma.
Anticancer Res. 30 (8): 3151-7 (2010)

■Immune Recovery Effects of Immunopotentiator from Pantoea agglomerans 1 (IPPA1) on Low Antibody Productions in Response to Salmonella Enteritidis Vaccine and Sheep Red Blood Cells in Dexamethasone-Treated Stressed Chicken Models.
Takehisa Hebishima, Yasunobu Matsumoto, Gen-Ichiro Soma, Chie Kohchi, Gen Watanabe, Kazuyoshi Taya, Yoshihiro Hayashi, Yoshikazu Hirota.
J Vet Med Sci. 72 (4): 435-42 (2010)

■Recovery from Immunosuppression-related Disorders in Humans and Animals by IP-PA1, An Edible Lipopolysaccharide.
Takehisa Hebishima, Yasunobu Matsumoto Gen Watanabe, Gen-Ichiro Soma, Chie Kohchi, Kazuyoshi Taya, Yoshihiro Hayashi, Yoshikazu Hirota.
Anticancer Res. 30 (8): 3113-8 (2010) 総説

■Comparative Immunological Analysis of Innate Immunity Activation after Oral Administration of Wheat Fermented Extract to Teleost Fish.
Takeshi Kadowaki, Yasumasa Yasui, Yukinori Takahashi, Chie Kohchi, Gen-Ichiro Soma, Hiroyuki Inagawa.
Anticancer Res. 29 (11): 4871-7 (2009)

■Intracellular Localization of CD14 Protein in Intestinal Macrophages.
Noriko Yoshioka, Yoshie Taniguchi1, Aya Yoshida, Kazue Nakata, Takashi Nishizawa, Hiroyuki Inagawa, Chie Kohchi1, Gen-Ichiro Soma.
Anticancer Res. 29 (3): 865-9 (2009)

■Utility and Safety of LPS-based Fermented Flour Extract as a Macrophage Activator.
Yoshie Taniguchi, Noriko Yoshioka, Takashi Nishizawa, Hiroyuki Inagawa, Chie Kohchi, Gen-Ichiro Soma.
Anticancer Res. 29(3):859-64 (2009) 総説

■Mechanism for Maintaining Homeostasis in the Immune System of the Intestine.
Yoshie Taniguchi, Noriko Yoshioka, Kazue Nakata, Takashi Nishizawa, Hiroyuki Inagawa, Chie Kohchi, Gen-Ichiro Soma.
Anticancer Res. 29 (11): 4855-60 (2009) 総説

■Intestinal Macrophages Involved in the Homeostasis of the Intestine Have the Potential for Responding to LPS.
Noriko Yoshioka, Yoshie Taniguchi, Aya Yoshida, Kazue Nakata, Takashi Nishizawa, Hiroyuki Inagawa, Chie Kohchi, Gen-Ichiro Soma.
Anticancer Res. 29 (11): 4861-5 (2009) 総説

■Improvement of Allergic Dermatitis via Regulation of the Th1/Th2 Immune System Balance by Macrophages Activated with Lipopolysaccharide Derived from Pantoea agglomerans (IP-PA1).
Aya Yoshida, Chie Kohchi, Hiroyuki Inagawa, Takashi Nishizawa, Gen-Ichiro Soma.
Anticancer Res. 29 (11): 4867-70 (2009) 総説

■Preventative and Therapeutic Potential of Lipopolysaccharide Derived from Edible Gram-Negative Bacteria to Various Diseases.
Soma, Gen-Ichiro, Inagawa, Hiroyuki, Nishizawa, Takashi, Yoshioka, Noriko, Taniguchi Yoshie; Kohchi Chie.
Current Drug Therapy, 3 (1) 26-32 (2008) 総説

■Development and Potential Use of a Monoclonal Antibody to the Lipopolysaccharide of Pantoea agglomerans (IP-PA1).
Yoshie Taniguchi, Takashi Nishizawa, Teruko Honda, Noriko Yoshioka, Hiroyuki Inagawa, Chie Kohchi, Gen-Ichiro Soma.
Anticancer Res. 27 (6A): 3701-6 (2007)

■Suppression of Response to Foreign Substances by Intestinal Macrophages.
Kazue Nakata1iroyuki Inagawa, Takashi Nishizawa, Chie Kohchi, Gen-Ichiro Soma.
Anticancer Res. 27 (6A): 3723-7 (2007) 総説

■マクロファージネットワークに基づいた食経験を持つグラム陰性菌リポ多糖の機能性食品素材（IP-PA1)への新展開.
稲川裕之, 河内千恵, 杣源一郎.
日本補完代替医療学会誌. 4 (2): 79-90 (2007) 総説

■Identification and Characterization of Lipopolysaccharide in Acetic Acid Bacteria.
Yoshie Taniguchi, Takashi Nishizawa, Chie Kouhchi1, Hiroyuki Inagawa, Takatoshi Yamaguchi, Shiro Nagai, Akihiro Tamura, Gen-Ichiro Soma.
Anticancer Res. 26 (6A): 3997-4002 (2006)

■Cloning and characterization of a LPS-regulatory gene having an LPS binding domain in kuruma prawn Marsupenaeus japonicus.
Hiroki Nagoshi, Hiroyuki Inagawa, Kayoko Morii, Hideaki Harada, Chie Kohchi, Takashi Nishizawa, Yoshie Taniguchi, Maya Uenobe, Teruko Honda, Masakazu Kondoh, Yukinori Takahashi, Gen-Ichiro Soma.
Mol Immunol. 43 (13): 2061-9 (2006)

■Unique Molecular Characteristics of the Environmental Responses of Mucosal Macrophages.
Kazue Nakata, Hiroyuki Inagawa, Takashi Nishizawa, Chie Kohchi, Yoshie Taniguchi, Noriko Yoshioka, Gen-Ichiro Soma.
Anticancer Res. 26 (6A): 4009-14 (2006) 総説

■Applications of Lipopolysaccharide Derived from Pantoea agglomerans (IP-PA1) for Health Care Based on Macrophage Network Theory.
Kohchi C, Inagawa H, Nishizawa T, Yamaguchi T, Nagai S, Soma G.
J Biosci Bioeng. 102 (6): 485-96 (2006) 総説

■A novel technology to prevent infectious diseases in aquaculture by modulating cytokines.
Inagawa H, Kondoh M, Kohchi C, Soma GI, Yuasa A, Takahashi Y. Innovations and Technologies in Oceanography for Sustainable Development, 29-43 (2005) 総説

■Utilization of Macrophages in Anticancer Therapy: The Macrophage Network Theory.
Chie Kohchi, Hiroyuki Inagawa, Mami Hino, Mutsumi Oda, Kazue Nakata, Aya Yoshida, Hitoshi Hori, Hiroshi Terada, Kimiko Makino, Kunio Takiguchi, Gen-Ichiro Soma.
Anticancer Res. 24 (5C): 3311-20 (2004) 総説

■マクロファージと健康維持.
杣源一郎, 稲川裕之, 河内千恵.
健康創造研究会誌. 2 (2): 105-112 (2003) 総説

■自然免疫における肺胞マクロファージの組織特異的性格.
杣源一郎, 稲川裕之, 河内千恵.
膜(MEMBRANE). 27(5): 108-117 (2002) 総説

■Enhancement of disease resistance against penaeid acute viraemia and induction of virus-inactivating activity in haemolymph of kuruma shrimp, Penaeus japonicus, by oral administration of Pantoea agglomerans lipopolysaccharide (LPS).
Takahashi Y, Kondo M, Itami T, Honda T, Inagawa H, Nishizawa T, Soma GI, Yokomizo Y.
Fish Shellfish Immunol. 10 (6): 555-8 (2000)

■ヒト腸管マクロファージのCD14の解析
南村昌志, 本田晃子, 稲川裕之, 坂田明子, 田代和弘, 高木幸一, 杣源一郎.
Biotherapy. 13 (5): 496-498 (1999)

■腸管マクロファージの性格一産生サイトカインによる解析一 本田晃子, 南村昌志, 稲川裕之, 坂田明子, 田代和弘, 高野正博, 高木幸一, 杣源一郎.
Biotherapy. 12 (5): 752-754 (1998)

■ヒト腸管からのマクロファージ画分の分離と精製の試み 南村昌志, 野口活夫, 稲川裕之, 本田晃子, 西澤孝志, 福島ゆかり, 加納順子, 高木幸一, 高野正博, 杣源一郎.
Biotherapy. 11 (3): 428-430 (1997)

■腸管マクロファージの性格-産生サイトカインおよび発現蛋白の予備的検討-
本田晃子, 西澤孝志, 稲川裕之, 高野正博, 高木幸一, 杣源一郎
Biotherapy. 11 (3): 431-433 (1997)

■Structural characterization of lipid A obtained from Pantoea agglomerans lipopolysaccharide.
Tsukioka D, Nishizawa T, Miyase T, Achiwa K, Suda T, Soma G, Mizuno D.
FEMS Microbiol Lett. 15;149 (2): 239-44 (1997)

■Anti-tumor effect of lipopolysaccharide by intradermal administration as a novel drug delivery system.
Inagawa H, Nishizawa T, Noguchi K, Minamimura M, Takagi K, Goto S, Soma G, Mizuno D.
Anticancer Res. 17 (3C): 2153-8 (1997)

■Antitumor Mechanism of Intradermal Administration of Lipopolysaccharide.
Inagawa H, Nishizawa T, Takagi K, Goto S, Soma G, Mizuno D.
Anticancer Res. 17 (3C): 1961-4 (1997)

■新規Lipid A誘導体ONO-4007の経口投与法によるTNF誘導効果の検討
南村昌志, 稲川裕之, 西澤孝志, 水野伝一, 杣源一郎.
Biotherapy. 10 (3): 376-378 (1996)

■Lipid A誘導体ONO-4007の皮内投与による抗腫瘍効果：（低分子LPSｐとの比較）
稲川裕之, 西澤孝志, 福島ゆかり, 本田晃子, 高木幸一, 水野伝一, 杣源一郎.
Biotherapy. 10 (3): 370-372 (1996)

■Intradermal administration of lipopolysaccharide in treatment of human cancer.
Shigenori Goto, Sumitaka Sakai, Jiro Kera, Yukie Suma, Gen-Ichiro Soma, Shoshichi Takeuchi.
Cancer immunol Immunother. 42 (4): 255-61 (1996)

■Pantoea agglomerans由来リポ多糖の低分子分画及び高分子分画リポ多糖の生物活性の検討
西澤孝志, 稲川裕之, 野口活夫, 池田耕一, 水野伝一, 杣源一郎.
Biotherapy. 10 (3): 519-521 (1996)

■Pantoea agglomerans由来リポ多糖（LPSｐ）によるMRSA感染抵抗性の増強
奥富隆文, 矢吹由香里, 大矢和光, 稲川裕之, 西澤孝志, 田辺浪子, 杣源一郎, 水野伝一.
Biotherapy. 8 (3): 356-357 (1996)

■Mechanistic analysis of high antitumor effect of intradermal administration of lipopolysaccharide from Pantoea agglomerans.
Iwamoto I, Goto S, Kera J, Soma G, Takeuchi S, Nagata Y.
Med Oncol. 13 (2): 103-9 (1996)

■進行性腎癌例に対する低分子Lipopolysaccharide (LPSp)の皮膚投与
加藤幹雄, 吉野修二, 岡田耕市, 後藤重則, 杣源一郎.
Biotherapy. 9 (3): 380-381 (1995)

■Pantoea agglomeransより抽出した低分子Lipopolysaccharide (LPSp)の皮膚投与によるがん患者における治療効果
家老仁郎, 後藤重則, 須磨幸恵, 酒井純孝, 杣源一郎, 竹内正七.
Biotherapy. 9 (3): 377-378 (1995)

■モルヒネ及びコカイン依存症治療薬としてのImmunomodulator. 特にLPSの効用について.
奥富隆文, 鈴木勉.
薬学雑誌. 115 (1): 42-51 (1995) 総説

■低分子Lipopolysaccharide (LPSp）皮内投与の抗腫瘍効果およびその臨床応用.
後藤重則
Biotherapy. 9 (2): 169-175 (1995) 総説

■ヒトにおける低分子lipopolysaccharide (LPSp)経口腔内投与によるTNF, β-エンドルフィンの誘導及び手術後の鎮痛効果
須磨幸恵, 後藤重則, 家老仁郎, 酒井純孝, 奥富隆文, 杣源一郎, 竹内正七.
Biotherapy. 8 (3): 348-349 (1994)

■Effects of a lipopolysaccharide from Pantoea agglomerans on the cocaine-induced place preference.
Suzuki T, Funada M, Sugano Y, Misawa M, Okutomi T, Soma G, Mizuno D.
Life Sci. 54 (6):PL75-80 (1994)

■Antinociceptive effect of lipopolysaccharide from Pantoea agglomerans on streptozotocin-induced diabetic mice.
Kamei J, Iwamoto Y, Suzuki T, Misawa M, Kasuya Y, Nagase H, Okutomi T, Soma G, Mizuno D.
Eur J Pharmacol. 4; 251 (1): 95-8 (1994)

■Suppression of hyperalgesia in streptozotocin-induced diabetic mice by a lipopolysaccharide from Pantoea agglomerans.
Kamei J, Iwamoto Y, Suzuki T, Misawa M, Kasuya Y, Okutomi T, Soma G, Mizuno D.
Biol Pharm Bull. 17 (5): 632-4 (1994)

■Pantoea agglomeranseより抽出した低分子lipopolysaccharide (LPSp)の皮内投与のがんに対する臨床応用
後藤重則, 千葉夕子, 酒井純孝, 須磨幸恵, 家老仁郎, 杣源一郎, 竹内正七.
Biotherapy. 8 (3): 325-326 (1994)

■Further Development of the Therapy with Lipopolysaccharides of a Small Molecular Size on Various Intractable Diseases.
Gen-Ichiro Soma, Den-ichi Mizuno.
Molecular and Cellular Biology and Clinical Relevance. p203-220 (1993) 総説

■Inhibition of morphine dependence by a lipopolysaccharide from Pantoea agglomerans.
Okutomi T1, Nishizawa T, Inagawa H, Soma G, Minami M, Satoh M, Mizuno D.
Eur Cytokine Netw. 3 (4): 417-20（1992）.

■Homeostasis as regulated by activated macrophage. I. Lipopolysaccharide (LPS) from Wheat Flour: Isolation, Purification and Some Biological Activities.
Nishizawa T1, Inagawa H, Oshima H, Okutomi T, Tsukioka D, Iguchi M, Soma G, Mizuno D.
Chem Pharm Bull. 40 (2): 479-83 (1992)

■Homeostasis as regulated by activated macrophage. II. LPS of Plant Origin Other than Wheat Flour and Their Concomitant Bacteria.
Inagawa H1, Nishizawa T, Tsukioka D, Suda T, Chiba Y, Okutomi T, Morikawa A, Soma GI, Mizuno D.
Chem Pharm Bull. 40 (4): 994-7 (1992)

■Homeostasis as regulated by activated macrophage. III. Protective Effect of LPSw (Lipopolysaccharide (LPS) of Wheat Flour) on Gastric Ulcer in Mice as Compared with Those of Other LPS from Various Sources.
Inagawa H1, Saitoh F, Iguchi M, Nishizawa T, Okutomi T, Morikawa A, Soma GI, Mizuno D.
Chem Pharm Bull. 40 (4): 998-1000 (1992)

■Homeostasis as regulated by activated macrophage. IV. Analgesic Effect of LPSw, a Lipopolysaccharide of Wheat Flour.
Okutomi T1, Nishizawa T, Inagawa H, Morikawa A, Takeuchi S, Soma GI, Mizuno D.
Chem Pharm Bull. 40 (4): 1001-3 (1992)

■Homeostasis as regulated by activated macrophage.V. Suppression of Diabetes Mellitus in Non-obese Diabetic Mice by LPSw (a Lipopolysaccharide from Wheat Flour).
Iguchi M1, Inagawa H, Nishizawa T, Okutomi T, Morikawa A, Soma GI, Mizuno D.
Chem Pharm Bull. 40 (4): 1004-6 (1992)

■Homeostasis as regulated by activated macrophage. VI. Protective Effect of LPSw (a Lipopolysaccharide from Wheat Flour) against Acute Infection by Toxoplasma gondii in Mice.
Suzuki Y1, Kobayashi A, Nishizawa T, Inagawa H, Morikawa A, Soma G, Mizuno D.
Chem Pharm Bull. 40 (5): 1266-7 (1992)

■Homeostasis as regulated by activated macrophage. VII. Suppression of Serum Cholesterol Level by LPSw (a Lipopolysaccharide from Wheat Flour) in WHHL (Watanabe Heritable Hyperlipidemic) Rabbit.
Okutomi T1, Nishizawa T, Inagawa H, Takano T, Morikawa A, Soma G, Mizuno D.
Chem Pharm Bull. 40 (5): 1268-70 (1992)

■Homeostasis as regulated by activated macrophage. VIII. LPSw (a lipopolysaccharide from wheat flour) can regulate bone resorption of chick embryo.
Kawashima K1, Endo H, Nishizawa T, Inagawa H, Okutomi T, Morikawa A, Soma G, Mizuno D.
Chem Pharm Bull. 40 (5): 1271-3 (1992)

■Homeostasis as regulated by activated macrophage. IX. Enhancement effect of LPSw (a lipopolysaccharide from wheat flour) on hen egg-laying and breaking strength of eggshell.
Suzuki J1, Nishizawa T, Inagawa H, Okutomi T, Morikawa A, Soma G, Mizuno D.
Chem Pharm Bull. 40 (5): 1274-6 (1992)

■Oral or percutaneous administration of lipopolysaccharide of small molecular size may cure various intractable diseases: a new version of Coley's toxin.
水野伝一, 杣源一郎.
Mol Biother. 4 (4): 166-9 (1992) 総説

■小麦及び諸種グラム陰性菌由来リポ多糖の経口投与によるマウスを用いた鎮痛効果 (Wrinthing test)の比較検討.
稲川裕之, 千葉夕子, 奥富隆文, 西澤孝志, 月岡大輔, 杣源一郎, 水野伝一.
Biotherapy. 6 (3): 358-359 (1992)

■小麦より分離したPantoea agglomeransの精製Lipopolysaccharideの生物活性の検討.
西澤孝志, 稲川裕之, 奥富隆文, 井口誠, 千葉夕子, 須田拓也, 月岡大輔, 杣源一郎, 水野伝一.
Biotherapy. 6 (3): 356-357 (1992)

■マクロファージ活性化作用を有する小麦粉由来リポ多糖（LPSｗ）の種々の疾患に対する治療または予防効果.
稲川裕之, 西澤孝志, 奥富隆文, 井口誠, 大島治之, 土橋一慶, 竹内正七, 杣源一郎, 水野伝一.
Biotherapy. 5 (4): 617-621 (1991)